à 11 c, 18 f, 68 ga , (4 ,% 6 / 6
TRANSCRIPT
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П о од т о ко т ол к л тет П 11C, 18F, 68Ga д оф це т ц
Це т п ту њ од о л т укле ед ц – П Це т , е тет Гоце елче
К те Коле к
Policlinico S.Orsola Malpighi – Bologna
PET Radiofarmacia
Ап л-М ј 5 од.
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Policlinico S.Orsola – Malpighi
U.O. Medicina Nucleare – PET Radiofarmacia
ј
ј
Е
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F-18
18O(p,n)18F
H218O [18 F]F-
: 109.8 min
ј
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[18 F]FDG
ј
:
1,3,4,6, -O- -2-O-
-D-
З
С
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[18 F]FDG
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К
NaOH
H3PO4
Е ( , , H2O, K2CO3)
QMA ј
C18
Ј
Alumina
њ
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Д њ ј
0.22 µm
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К [18 F]FDG
Х :
→ HPLC
→ Kriptofix
:
→ HPLC
→ TLC
pH
ј
→ γ ј
→
( )
ј
Х :
( , ,
) → GC
→ γ ј
→ Endosafe (LAL )
ј
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К
HPLC (
)
ј ( њ
)
pH
Endosafe ( LAL )
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ј
[18 F]FDG
[18 F]FDG
Глуко а
• ек ок а а
Глуко а-6-
о ат
•Глуко а-6- о ат о е а а
Ф укто а-
6- о ат
[18F]FDG
• ек ок а а
[18F]FDG-6-
phosphate
•Глуко а-6- о ат-
о е а а
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[11C] C-11
11C -
N2+O2 (0.5-1%) LiAlH4, HI
11CO2 “в а а” а а
14N(p,α)11C 11CH3I
11CH4 I2
N2+H2 (5-10%) “ ва” а а
11CH3I + HO – CH2 - R 11CH3O - CH2 - R С а 11C- а и а ац в и
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[11C]Choline [11C]Choline
SPE (solid-phase extraction) : C18 ј
CH3
CH3
11CH3I +
N CH2 CH2 OH 11CH3 N CH2 CH2 OH
CH3
CH3
+ I‾
DMAE [11C]Choline
С ј 0.22 µm
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Х
К
Х
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К [11C]Choline
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Ga-68
Г
68Ge (
270.95 )
68Ga ( 67.71 min)
68Zn ( )
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[68Ga ]DOTA-NOC
→
DOTA
1.Е ј
2. њ њ
3. њ
4. њ
ј
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К [68Ga ]DOTA-NOC
ј
:
- HPLC - TLC
pH
ј :
–
– γ ј
ј
–
( , )
:
γ ј
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/
П F-18, C-11, Ga-68 С ,
[18 F]FDG, [11C]Choline , [11C]Methionine,
[68Ga ]DOTA-NOC